Exploring the Role of B. Pertussis in Alzheimer’s Disease

Our peer-reviewed publication has laid the foundation for research currently underway.

Cross-sectional illustration of the human head demonstrating B. pertussis inhalation and its localization to the superior nasal cavity.

As illustrated above, secreted pertussis toxin (BP toxin) from a colonizing virulent nasopharyngeal B. pertussis infection (BP) may access the CNS via the olfactory tract (black arrows) through channels in the cribriform plate, and localize to the olfactory bulb and its projections including the entorhinal cortex, hippocampus and amygdala. Early evidence suggests that pertussis toxin localization to and progression along neuroanatomic connections may lead to hallmark Alzheimer's pathology.

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